By: Fábio Albergaria de Queiroz (08/08/2024). This article analyzes transnational illicit activities in the Amazon, a space where diverse criminal networks thrive. As a research proposal, it is verified, through descriptive (how) and causal (why) inferences, to what extent the Amazon Cooperation Treaty Organization (ACTO) can become an effective tool to combat them, replacing the Union of South American Nations (UNASUR), which before the suspension of its activities was the appropriate forum for this purpose. […]